| Record no |
2012011690715 |
| Activity status |
Active |
| Working Title |
A SHORTEST PROCESS FOR THE ENANTIOSELECTIVE SYNTHESIS OF (S)-N-(5-CHLOROTHIOPHENE-2-SULPHONYL)-Β,Β-DIETHYLALANIOL (7.B.2) A DRUG ON ALZHEIMER’S DISEASE (AD) |
| Working Inventors |
VARUN RAWAT;PANDURANG V CHOUTHAIWALE;GURUNATH SURYAVANSHI;ARUMUGAM SUDALAI;VILAS BHIKU CHAVAN; |
| Contributing institutions |
NCL |
| Administered by |
CSIR |
| Ownership |
|
| Categories > Subjects |
Organic chemistry |
| Categories > Portfolio |
Fine chemical/pharma intermediate drugs/bioactives |
| Disclosure number |
2010-INV-0039 |
| NCL No |
2011-NCL-0018 |
| CSIR No |
2011-NF-0099
|
| Priority date |
06-21-2011 |
| Country |
US |
| Application number |
13/273022 |
| Provisional filing date |
|
| Complete filing date |
10-13-2011 |
| Publication status |
Yes |
| Publication date |
05-14-2013 |
| Publication no |
8440844 B2 |
| Granted number |
8440844 |
| Granted date |
05-14-2013 |
| Final title |
PROCESS FOR THE PREPARATION OF BETA-AMINO ALCOHOL |
| Final Inventors |
VARUN RAWAT;PANDURANG V CHOUTHAIWALE;GURUNATH SURYAVANSHI;ARUMUGAM SUDALAI;VILAS BHIKU CHAVAN; |
| Abstract |
A highyielding enantioselective synthesis of the bioactive S—N5chlorothiophene2sulfonyl ββdiethylalaniol 7.b.2 a Notch1sparing γsecretase inhibitor metabolite with EC5028 nM effective in reduction of Aβ production in vivo has been realized starting from readily available 3pentanone. The key steps of the synthesis are prolinecatalyzed αaminooxylation and αamination of aldehyde the latter contributing an overall yield of 5075 and 9099 enantiomeric excess. |
| Case status |
Granted + Inforce |
| Licensing status |
|
| Licensing case no |
|
| Client name |
|
| Lead inventors |
ARUMUGAM SUDALAI |
| Categories > Industry > Primary |
Medical Biotechnology,Biomed Products,Medical/Healthcare |
| Categories > Industry > other |
Pharmaceuticals |