| Record no |
201103074333 |
| Activity status |
Active |
| Working Title |
PROCESS FOR PREPARING L- ( + ) -LACTIC ACID |
| Working Inventors |
BARVE, PRASHANT, PURUSHOTTAM;KULKARNI, BHASKAR, DATTATREYA;NENE, SANJAY, NARAYAN;SHINDE, RAVINDRA, WILLIAM;GUPTE, MILIND, YASHWANT;JOSHI, CHANDRASHEKHAR, NARAYAN;THITE, GANDHALI, ARUN;CHAVAN, VILAS, BHIKU;DESHPANDE, TUSHAR, RAMCHANDRA; |
| Contributing institutions |
NCL |
| Administered by |
|
| Ownership |
|
| Categories > Subjects |
Chemical engineering and process development |
| Categories > Portfolio |
Fine chemical/pharma intermediate drugs/bioactives |
| Disclosure number |
2005-INV-0040 |
| NCL No |
2005-NCL-0040 |
| CSIR No |
2005-NF-0269
|
| Priority date |
07-20-2005 |
| Country |
WO |
| Application number |
PCT/IN05/00455 |
| Provisional filing date |
|
| Complete filing date |
12-30-2005 |
| Publication status |
Yes |
| Publication date |
01-25-2007 |
| Publication no |
WO/2007/010548 |
| Granted number |
|
| Granted date |
|
| Final title |
PROCESS FOR PREPARING L- ( + ) -LACTIC ACID |
| Final Inventors |
BARVE, PRASHANT, PURUSHOTTAM;KULKARNI, BHASKAR, DATTATREYA;NENE, SANJAY, NARAYAN;SHINDE, RAVINDRA, WILLIAM;GUPTE, MILIND, YASHWANT;JOSHI, CHANDRASHEKHAR, NARAYAN;THITE, GANDHALI, ARUN;CHAVAN, VILAS, BHIKU;DESHPANDE, TUSHAR, RAMCHANDRA; |
| Abstract |
The present invention provides a commercially viable process for the preparation of highly pure and optically active L lactic acid and S methyl lactate in high yield obtained from esterification of aqueous crude lactic acid solution produced by sugar cane juice fermentation broth and methanol in continuous counter current trickle phase approach or in continuous counter current bubble column manner using stabilizers and the methyl lactate so obtained is recovered and followed by purification of reasonably pure methyl lactate using reagent mixture such as sodium bi carbonate mono ethanolamine or di ethanolamine urea or sodium bicarbonate mono ethanolamine or di ethanolamine thiourea to reduce the impurity of dimethyl ester of dicarboxylic such as dimethyl oxalate or di methyl succinate or methyl ester of mono carboxylic acid such as methyl pyruvate present as an impurity so as to get highly pure S methyl lactate followed by hydrolyzing highly pure S methyl lactate using highly pure lactic acid as a catalyst using highly pure water as the hydrolysis media and by using pre treated activated carbon with dilute L lactic acid in batch or continuous mode. This very high pure S methyl lactate constitutes an important product having interesting possibilities of application at an industrial level in pharmaceuticals. Highly pure L lactic acid thus obtained is used as an acidulant as a food additive for pharmaceutical applications a monomer for making poly lactic acid as a monomer to prepare biodegradable polymer which are useful for manufacturing bags application films in the field of sanitary field and has medical applications. |
| Case status |
Complete specification filed |
| Licensing status |
|
| Licensing case no |
|
| Client name |
|
| Lead inventors |
PRASHANT PURUSHOTTAM BARVE |
| Categories > Industry > Primary |
Petrochemicals |
| Categories > Industry > other |
|